Indications

Treatment of vitamin C deficiency: fatigue during influenza or convalescence, infectious diseases.

Present

Blister of 10 film– coated tablets. Box of 10 blisters.

Composition

Ascorbic acid (Vitamin C)…………………..…….….500mg
Excipients s.q. for ……………………………..………1 tablet
(Low– substituted hydroxypropyl cellulose, Povidone, Microcrystalline cellulose, Crospovidone, Colloidal silicon dioxide, Magnesium stearate, Sepifilm LP 770, Hypromellose, Erythrosine, Sunset yellow, Titanium dioxide, Talc, Polyethylene glycol 6000, Ethanol 96%).

Actions

– Vitamin C is a water– soluble vitamin with strong redox capacity and it takes part in a number of biochemical reactions mostly involving oxidation. It is related to the synthesis of collagen, proteoglycans and other organic constituents of the intracellular matrix of diverse tissue as tooth, bone and capillary endothelium or tissue repair.
– Vitamin C has a direct effect on collagen peptide synthesis and influences protein hydroxylation indirectly.
– Vitamin C is not significantly stored by the body. It must be replenished regularly through diet or other means to maintain essential tissue levels. Thus this vitamin is rapidly depleted in conditions interfering with its intake or absorption. The most common symptoms of vitamin C deficiency are prolonged or imperfect wound healing defects in tooth– formation, cessation of bone growth, extreme vessel wall fragility, leakage from capillaries, susceptibility to infections.

Contra-Indications

Prolonged use of large doses of vitamin C is contra– indicated in:
– Patients with Glucose– 6– phosphate dehydrogenase deficiency.
– Patients with history of renal calculi, hyperoxaluria and primary oxalosis.
– Patients with thalassemia.

Side effect

– Digestive disorders: gastric burning, diarrhea.
– Hyperoxaluria.
Inform your doctor about side– effects when using this medicine.

Precaution

– Due to a mild stimulant effect, it is preferable not to take the drug at the end of the day or on empty stomach.
– If untoward symptoms occur as a result of overdose, discontinue use of vitamin C.
PREGNANCY AND LACTATION:
Avoid using of large doses of vitamin C during pregnancy and lactation.

Interaction

– Concurrent administration of vitamin C and Aspirin is known to result in increased urinary excretion of the former and decreased excretion of the latter.
– Coadministration of vitamin C and Fluphenazine may lead to decreased Fluphenazine plasma concentration.
– Concurrent administration of more than 200mg of vitamin C per 30mg of elemental iron increases absorption of iron from the GI tract.
– Large doses of vitamin C may destroy substantial amount of vitamin B12 in vitro.
OVERDOSAGE & MANAGEMENT:
Symptoms of vitamin C overdose include: kidney stones, nausea, gastritis and diarrhea. Forced diuresis by infusion may be effective after ingestion of large doses of vitamin C.

Shelf life

24 months from the manufacturing date.

Storage

Store in a dry place (RH ≤ 70%), not exceeding 30^oC. Protect from light.

Dosage

– Adults: 1 – 2 tablets daily.
– Children: 1/2 – 1 tablet daily