Indications

Dermatoses responsive to topical corticoid therapy and are secondarily infected such as eczema, psoriasis, contact dermatitis, atopic dermatitis, neurodermatitis, seborrheic dermatitis, stasis dermatitis, solar dermatitis, insect bites and senile pruritus.

Present

Tube of 10g of cream. Box of 1 tube.

Composition

Betamethasone dipropionate ……………………………..6.4mg
Neomycin sulfate ……………………………………………..50mg
Excipients s.q. for………………………………………………..10g
(Polysorbate 80, EDTA sodium, Sodium metabisulfite, Sodium sulfite, White soft paraffin, Cetostearyl alcohol, Cetomacrogol 1000, Paraffin, Propylene glycol, Glycerin, Purified water).

Pharmacology

– Betamethasone is a synthetic corticosteroid with mainly glucocorticoid activity that has anti– inflammatory, anti– rheumatic and anti– allergic activity.
– Neomycin is an aminoglycoside antibiotic against a wide variety of gram– positive and gram– negative bacteria that cause infections of the skin.

Pharmacokinetics

– Topical Betamethasone can be absorbed through the skin. Its percutaneous absorption may be increased by the use of occlusive dressings or the skin is not intact that result in a substantial amount of Betamethasone is absorbed to produce systemic effects.
– Neomycin is not absorbed following topical applications to intact skin. However, the drug is readily absorbed through denuded or abraded skin or skin that has lost the keratin layer as in wounds, burns, or ulcers.

Contra-Indications

– Hypersensitivity to any ingredient of the medicine.
– Primary skin lesion caused by microbial, fungal and viral infection; ulcerating wounds; acne.
– Do not use MEKODERM– NEOMYCIN for ophthalmology.
– Dermatosis in infants under 1 year old.

Side effect

Rare:
– Burning sensation, itching, irritation, dryness, folliculitis, hypertrichosis, pustular eruption, hypopigmentation, perioral dermatitis, contact dermatitis, secondary skin infection, skin atrophy, striae. Oto– , nephrotoxicity and hypersensitivity reactions.
– Adrenal suppression, especially in children.
Inform your doctor about side– effects when using this medicine.

Precaution

– Caution should be exercised when the drug is used in patient with history of allergic reaction to any drug or cosmetics such as urticaria, dermotoxicosis.
– For external use only, not intended to be taken orally.
– Caution should be exercised when corticoid applied onto extended area or occluded bandage is used because of possible systemic effects.
– If eye contamination is accidentally occurred, flush the affected eye liberally with water or warm water.
– For pediatric use, use only under strict surveillance of adult.
– Discontinue the drug if urticaria, pruritus or irritation persist.
PREGNANCY AND LACTATION:
Caution should be exercised when it is given during pregnancy and lactation.

Interaction

– Interactions may occur during prolonged use or on extensive body surface areas. These cases may cause systemic absorption. There is no report available about interaction with other drugs if used as directed.
Inform your doctor or pharmacist about other drugs you are taking to avoid possible interactions.
OVERDOSAGE:
– No report about the overdosage of the drug.
– Should overdosage occur, turn to the nearest healthcare facility for medical attention of the healthcare professionals.

Shelf life

24 months from the manufacturing date.

Storage

Store in a dry place (RH ≤ 70%), not exceeding 30^oC. Protect from light.

Dosage

– Apply to affected area: 2 – 3 times daily.
– The treatment should not exceed 7 days.