Indications

Treatment of Nicotinamide deficiency (pellagra,…).

Present

Bottle of 30 tablets. Box of 1 bottle.

Composition

Nicotinamide……………………………………..500mg
Excipients s.q. for……………………………..1 tablet
(Lactose, Sodium starch glycolate, Ethanol 96%, Povidone, Microcrystalline cellulose, Magnesium stearate).

Actions

Nicotinamide, a water– soluble vitamin B, is naturally occurring in the body, or is formed by partially oxidation of Tryptophan, found in food. In the body, Nicotinamide is converted to NAD or NADP. These are coenzymes that involved in electron transfer reactions in the respiratory chain of cells, glycogenolysis and lipid biotransformation.

Contra-Indications

– Hypersensitivity to Nicotinamide.
– Severe liver disease.
– Active peptic ulcer.
– Arterial hemorrhage.
– Severe hypotension.

Side effect

– Small oral doses of Nicotinamide are usually nontoxic.
– Large doses may cause some side– effects (these unwanted effects disappear after medicine discontinuation):
+ Common: nausea, flushing of the face and neck, pruritus, sensation of burning, stinging or tingling of the skin.
+ Occasional: active peptic ulcer, vomiting, anorexia, abdominal cramps, bloating, diarrhea, dry skin, hyperpigmentation, jaundice, liver dysfunction, glucose intolerance, seborrhea, hyperglycemia, hyperuricemia, headache and blurred vision, hypotension, tachycardia, syncope, dizziness,…
+ Rare: anxiety, glycosuria, abnormal liver function test results, abnormal prothrombin time, hypoalbuminaemia, anaphylactic shock,…
Inform your doctor about side– effects when using this medicine.

Precaution

– ​Large doses of Nicotinamide should be administered with caution in following cases:
– Patients with gallbladder disease, a history of jaundice or liver disease, diabetes mellitus, gout, peptic ulcer.
– Drivers or operators of machinery.
PREGNANCY AND LACTATION:
Generally, consult the doctor before taking any medication during pregnancy and lactation.

Interaction

– Do not take concomitantly with HMG– CoA reductase inhibitors, Carbamazepine, antihypertensive therapy, hepatotoxic agents.
– Dosage requirements for oral hypoglycaemic agents or insulin should be adjusted in diabetic patients.
OVERDOSAGE & MANAGEMENT:
Should overdosage occur, turn to the nearest healthcare facility for medical attention of the healthcare professionals such as: induced emesis, gastric lavage, symptomatic and supportive measure should be undertaken.

Shelf life

– 24 months from the manufacturing date.
Never use after the expiry date clearly indicated on the outer packaging.

Storage

Store in a dry place (RH ≤ 70%), not exceeding 30^oC. Protect from light.

Dosage

Adults: 1 tablet, 1 – 3 times daily. The daily dosage should not exceed 3 tablets.